UNIST researchers have discovered a crucial element in the DNA damage response, specifically in homologous recombination and DNA interstrand crosslink repair. Their findings are anticipated to create an efficient means of managing chromosome instability – a significant contributor to cancer progression – and ultimately aid in the fight against malignant tumors.
Professors Hongtae Kim and Kyungjae Myung of UNIST’s Department of Biological Sciences, along with Professor Yonghwan Kim and his research team from Sookmyung Women’s University, jointly led the research that resulted in this discovery, which was published in the January 2023 issue of Nucleic Acids Research.
The research team showcased in their study that ZNF212, a new interaction partner of TRAIP, plays significant roles in DNA damage signaling and HR for cell survival and genome maintenance. It is believed that ZNF212 acts upstream of both NEIL3 and FA pathways for ICL repair.
The team also found that TRAIP serves as a crucial regulatory factor for ICL repair upstream of both NEIL3 and FA pathways in mESC lines. Additionally, TRAIP acts as the master regulator in ICL repair, according to their findings.
“Our findings together with mESC lines used in this study will be informative to understand molecular basis of the ICL repair pathways in detail,” noted the research team.
Funding for this research was provided by the National Research Foundation of Korea (NRF), the Institute of Basic Science (IBS), and the Korean government (MSIT). The results have been published online in Nucleic Acids Research, a highly respected journal within the fields of biochemistry and molecular biology.